pI: 6.5349 |
Length (AA): 703 |
MW (Da): 82768 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 701 | 1dn1 (A) | 4 | 586 | 29.00 | 0 | 1 | 1.07 | -0.33 |
2 | 137 | 1y9j (A) | 9 | 146 | 22.00 | 0 | 0.84 | 0.35 | -1.05 |
1 | 703 | 4jeh (A) | 4 | 588 | 27.00 | 0 | 1 | 1.0275 | 0.18 |
1 | 701 | 2xhe (A) | 1 | 615 | 23.00 | 0 | 1 | 1.03166 | 0.11 |
2 | 135 | 1y9j (A) | 9 | 147 | 21.00 | 0.00000033 | 0.97 | 0.447112 | -0.64 |
14 | 700 | 3puk (A) | 22 | 580 | 31.00 | 0 | 1 | 0.91104 | 1.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | sporozoite, Oocyst, Sporozoite, Female Gametocyte. | PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, Ring, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127453)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G12360 | SNARE-interacting protein KEULE |
Arabidopsis thaliana | AT4G12120 | protein transport sec1b |
Arabidopsis thaliana | AT1G02010 | protein transporter sec1a |
Babesia bovis | BBOV_I002210 | syntaxin binding protein, putative |
Brugia malayi | Bm1_16115 | acetylcholine regulator unc-18 |
Candida albicans | CaO19.6479 | SNARE binding, late stage of secretion |
Candida albicans | CaO19.13833 | SNARE binding, late stage of secretion |
Candida albicans | CaO19_6479 | hypothetical protein |
Caenorhabditis elegans | CELE_F27D9.1 | Protein UNC-18, isoform B |
Cryptosporidium hominis | Chro.80127 | syntaxin binding protein |
Cryptosporidium parvum | cgd8_1080 | STXBP/UNC-18/SEC1 syntaxin involved in golgi transport |
Dictyostelium discoideum | DDB_G0283937 | Sec1-like family protein |
Drosophila melanogaster | Dmel_CG15811 | Ras opposite |
Echinococcus granulosus | EgrG_000380500 | syntaxin binding protein 1 |
Entamoeba histolytica | EHI_093130 | Sec1 family protein |
Echinococcus multilocularis | EmuJ_000380500 | syntaxin binding protein 1 |
Homo sapiens | ENSG00000136854 | syntaxin binding protein 1 |
Homo sapiens | ENSG00000076944 | syntaxin binding protein 2 |
Leishmania braziliensis | LbrM.26.2180 | syntaxin binding protein 1, putative |
Leishmania donovani | LdBPK_262270.1 | syntaxin binding protein 1, putative |
Leishmania infantum | LinJ.26.2270 | syntaxin binding protein 1, putative |
Leishmania major | LmjF.26.2260 | Sec1/Munc18 related protein, putative |
Leishmania mexicana | LmxM.26.2260 | syntaxin binding protein 1, putative |
Loa Loa (eye worm) | LOAG_08180 | uncoordinated protein 18 |
Loa Loa (eye worm) | LOAG_07804 | acetylcholine regulator unc-18 |
Mus musculus | ENSMUSG00000026797 | syntaxin binding protein 1 |
Mus musculus | ENSMUSG00000004626 | syntaxin binding protein 2 |
Neospora caninum | NCLIV_016920 | hypothetical protein |
Oryza sativa | 4335313 | Os04g0252400 |
Oryza sativa | 4340037 | Os06g0135900 |
Plasmodium berghei | PBANKA_0112000 | syntaxin binding protein, putative |
Plasmodium falciparum | PF3D7_0613700 | syntaxin binding protein, putative |
Plasmodium knowlesi | PKNH_1136300 | syntaxin binding protein, putative |
Plasmodium vivax | PVX_113820 | syntaxin binding protein, putative |
Plasmodium yoelii | PY05107 | syntaxin binding protein 1 |
Saccharomyces cerevisiae | YDR164C | Sec1p |
Schistosoma japonicum | Sjp_0007200 | Protein ROP, putative |
Schistosoma mansoni | Smp_131870 | syntaxin binding protein-123 |
Schmidtea mediterranea | mk4.001900.05 | |
Schmidtea mediterranea | mk4.001950.04 | Protein ROP |
Schmidtea mediterranea | mk4.003677.01 | Protein ROP |
Schmidtea mediterranea | mk4.001950.03 | Protein ROP |
Trypanosoma brucei gambiense | Tbg972.9.660 | syntaxin binding protein 1, putative |
Trypanosoma brucei | Tb927.9.1970 | syntaxin binding protein 1, putative |
Trypanosoma congolense | TcIL3000_9_450 | syntaxin binding protein 1, putative |
Trypanosoma cruzi | TcCLB.506737.140 | syntaxin binding protein 1, putative |
Toxoplasma gondii | TGME49_240740 | Sec1 family protein |
Theileria parva | TP03_0108 | syntaxin binding protein, putative |
Trichomonas vaginalis | TVAG_364050 | syntaxin binding protein-1,2,3, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.0780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.0780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.0780 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.0780 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F27D9.1 | Caenorhabditis elegans | sterile | wormbase |
YDR164C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_240740 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.